New vehicle time.. whats the best for me?

Hey as of recently you have seen my first post about the 72 f-250. I need to buy a new truck what would be the best for business.? I would like something good on gas yet spacious but not to small... enough to fit up to 4 appliances at a time.

I am open to cargo vans too..

I just need to know which way to go since i am "old school" i don't need the bells and whistles, I just need the space.

1995 Ford E150 Cargo Van w/300 Straight 6...about 15mpg.

Largest load volume wise was 3 fridges, 3 dryers, a washer and a dishwasher. Largest weight load to date was 3000#'s.

loaded like semi i keep putting my eyes on one of those the ones that seperate the back from the front with a gate

i am looking into diesel f250s and ram 2500"s for fuel vs space argument